The Benefits of Bacillus-derived Hyaluronic Acid in Adding New and Improved Attributes to Existing Drug Formulations and Offering Opportunities for New Delivery System Development
نویسنده
چکیده
Hyaluronic acid (HA or hyaluronan) is a natural, high molecular weight, linear polysaccharide composed of alternating N-acetyl glucosamine and glucuronic acid disaccharide units. HA is ubiquitous in human and animal tissues. It is found in the vitreous body, in the extracellular matrix of soft connective tissues, and in the synovial fluids. By supplementing the body’s level of glycosaminoglycan and providing water-binding, viscoelastic and biological properties, HA serves as a major ingredient in medical devices and pharmaceuticals. HA exhibits significant structural, rheological, physiological, and biological functions. These, coupled with its lack of immunogenicity and toxicity, make HA a very attractive carrier for drug delivery applications:
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